I'm doing some web design experimentation with Joomla, Drupal, and Moodle. As I am exploring these open-source applications, I also have an interest in converting some Microsoft Access databases into MySQL.
The big application would be a simplified, self-service helpdesk system which would allow users to pick a major category, sub-category, and task for which they need tips / advice. I think this is easier to build and populate in Access and the "push" into a MySQL database. (Or at least those are my thoughts for the moment - unless other can recommend some really easy GUI-based MySQL interfaces which allow CSV imports.)
Here are some articles I've come across relating to converting Microsoft Access to MySQL.
MySql: Migrating from Microsoft SQL ServerBullzip.com tool Access To MySQLDrupal Taxonomy Quick Find module
Joomla FAQ Extensions
Joomla MultiSites Extensions (helpdesk as separate site from main)