The variables RangeToPrint and HeadingsAtTop are automatically calculated at the time the macro is run - so it works with spreadsheet worksheets of all sizes and shapes.
Here is the code:
Sub StandardReportLayout()
'
' StandardReportLayout Macro
' Autowidth Columns and color top header
'
Dim x As Long, lastCell As Range, RangeToPrint As Range, HeadingsAtTop As Range
x = ActiveSheet.UsedRange.Columns.Count
Set lastCell = Cells.SpecialCells(xlCellTypeLastCell)
Set HeadingsAtTop = Range(Cells(1, 1), Cells(1, x))
Set RangeToPrint = Range(Cells(1, 1), lastCell)
'
HeadingsAtTop.Select
With Selection
.HorizontalAlignment = xlGeneral
.VerticalAlignment = xlBottom
.WrapText = True
.Orientation = 0
.AddIndent = False
.IndentLevel = 0
.ShrinkToFit = False
.ReadingOrder = xlContext
.MergeCells = False
End With
With Selection.Interior
.Pattern = xlSolid
.PatternColorIndex = xlAutomatic
.ThemeColor = xlThemeColorAccent1
.TintAndShade = 0.599993896298105
.PatternTintAndShade = 0
End With
With Selection.Interior
.Pattern = xlSolid
.PatternColorIndex = xlAutomatic
.ThemeColor = xlThemeColorLight2
.TintAndShade = 0.799981688894314
.PatternTintAndShade = 0
End With
Selection.Font.Bold = True
ActiveWindow.LargeScroll ToRight:=0
Range("A1").Select
Selection.End(xlToRight).Select
Range(Selection, Cells(ActiveCell.Row, 1)).Select
Selection.Borders(xlDiagonalDown).LineStyle = xlNone
Selection.Borders(xlDiagonalUp).LineStyle = xlNone
With Selection.Borders(xlEdgeLeft)
.LineStyle = xlContinuous
.ColorIndex = 0
.TintAndShade = 0
.Weight = xlThin
End With
With Selection.Borders(xlEdgeTop)
.LineStyle = xlContinuous
.ColorIndex = 0
.TintAndShade = 0
.Weight = xlThin
End With
With Selection.Borders(xlEdgeBottom)
.LineStyle = xlContinuous
.ColorIndex = 0
.TintAndShade = 0
.Weight = xlThin
End With
With Selection.Borders(xlEdgeRight)
.LineStyle = xlContinuous
.ColorIndex = 0
.TintAndShade = 0
.Weight = xlThin
End With
With Selection.Borders(xlInsideVertical)
.LineStyle = xlContinuous
.ColorIndex = 0
.TintAndShade = 0
.Weight = xlThin
End With
With Selection.Borders(xlInsideHorizontal)
.LineStyle = xlContinuous
.ColorIndex = 0
.TintAndShade = 0
.Weight = xlThin
End With
RangeToPrint.Select
Selection.Columns.AutoFit
ActiveWindow.LargeScroll ToRight:=-1
Columns("A:A").Select
Range(Selection, Selection.End(xlToRight)).Select
Selection.Columns.AutoFit
Range("A1").Select
Range(Selection, Selection.End(xlDown)).Select
Range(Selection, Selection.End(xlToRight)).Select
ActiveSheet.PageSetup.PrintArea = RangeToPrint.Address
Application.PrintCommunication = False
With ActiveSheet.PageSetup
.PrintTitleRows = "$1:$1"
.PrintTitleColumns = ""
End With
With ActiveSheet.PageSetup
.PrintTitleRows = "$1:$1"
.PrintTitleColumns = ""
End With
Application.PrintCommunication = True
ActiveSheet.PageSetup.PrintArea = RangeToPrint.Address
Application.PrintCommunication = False
With ActiveSheet.PageSetup
.LeftHeader = "&Z&F &A"
.CenterHeader = ""
.RightHeader = ""
.LeftFooter = "Page &P of &N - &D &T"
.CenterFooter = ""
.RightFooter = ""
.LeftMargin = Application.InchesToPoints(0.25)
.RightMargin = Application.InchesToPoints(0.25)
.TopMargin = Application.InchesToPoints(0.75)
.BottomMargin = Application.InchesToPoints(0.75)
.HeaderMargin = Application.InchesToPoints(0.3)
.FooterMargin = Application.InchesToPoints(0.3)
.PrintHeadings = False
.PrintGridlines = True
.PrintComments = xlPrintNoComments
.PrintQuality = 600
.CenterHorizontally = False
.CenterVertically = False
.Orientation = xlLandscape
.Draft = False
.PaperSize = xlPaperLetter
.FirstPageNumber = xlAutomatic
.Order = xlDownThenOver
.BlackAndWhite = False
.Zoom = 100
.PrintErrors = xlPrintErrorsDisplayed
.OddAndEvenPagesHeaderFooter = False
.DifferentFirstPageHeaderFooter = False
.ScaleWithDocHeaderFooter = True
.AlignMarginsHeaderFooter = False
.EvenPage.LeftHeader.Text = ""
.EvenPage.CenterHeader.Text = ""
.EvenPage.RightHeader.Text = ""
.EvenPage.LeftFooter.Text = ""
.EvenPage.CenterFooter.Text = ""
.EvenPage.RightFooter.Text = ""
.FirstPage.LeftHeader.Text = ""
.FirstPage.CenterHeader.Text = ""
.FirstPage.RightHeader.Text = ""
.FirstPage.LeftFooter.Text = ""
.FirstPage.CenterFooter.Text = ""
.FirstPage.RightFooter.Text = ""
End With
Application.PrintCommunication = True
End Sub

